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Identification of immunogenetic factors mediating rodent susceptibility to hantaviruses
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This file deals with the following question :
- Is it possible to identify factors mediating genetic susceptibility of rodents to
hantaviruses
- by studying the genes involved in the immune response
- using phylogeny, phylogeography and population genetics ?
The documents below provide three levels of information on rodents' susceptibility to hantaviruses, namely :
[Article] 1.- A bibliographic review on hantavirus-induced immune responses in
rodent reservoir (to help determine candidate genes)
[Slideshow] 2.- A candidate gene approach applied over the macro-evolutive scale(between species) :
the case of integrins.
3.- A candidate gene approach applied over the micro-evolutive scale (within species):
the case of Mhc genes and Myodes glareolus at various scales :
[Article] a) Experimental infection.
[Article] b) 'Local' scale in Jura - France
[Slideshow] c) Regional scale in Europe
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